| Reaction Details |
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 | Report a problem with these data |
| Target | D-amino-acid oxidase |
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| Ligand | BDBM50431083 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_947854 (CHEMBL2343130) |
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| IC50 | 16±n/a nM |
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| Citation |  Hondo, T; Warizaya, M; Niimi, T; Namatame, I; Yamaguchi, T; Nakanishi, K; Hamajima, T; Harada, K; Sakashita, H; Matsumoto, Y; Orita, M; Takeuchi, M 4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors. J Med Chem56:3582-92 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D-amino-acid oxidase |
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| Name: | D-amino-acid oxidase |
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| Synonyms: | D-Amino Acid Oxidase (DAAO) | DAMOX | Dao | Dao1 | OXDA_RAT |
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| Type: | Homodimer |
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| Mol. Mass.: | 38824.91 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Recombinant rat DAAO expressed and purified from sf9 insect cells, was used in enzyme assays. |
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| Residue: | 346 |
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| Sequence: | MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSN
PQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSE
LDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINC
TGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGV
FQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSS
SAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
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| BDBM50431083 |
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| n/a |
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| Name | BDBM50431083 |
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| Synonyms: | CHEMBL2338803 | US10202399, Example 24 | US10463663, Example 8 | US11129828, Example 8 | US9212147, 24 | US9290456, 8 | US9931340, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10F2N2O2 |
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| Mol. Mass. | 252.2168 |
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| SMILES | Oc1cc(CCc2cc(F)cc(F)c2)n[nH]c1=O |
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| Structure | 
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