| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 3 [N508S] |
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| Ligand | BDBM50431676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_951489 (CHEMBL2350642) |
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| Ki | 1150±n/a nM |
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| Citation |  Yu, W; Smil, D; Li, F; Tempel, W; Fedorov, O; Nguyen, KT; Bolshan, Y; Al-Awar, R; Knapp, S; Arrowsmith, CH; Vedadi, M; Brown, PJ; Schapira, M Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorg Med Chem21:1787-94 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 3 [N508S] |
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| Name: | Protein arginine N-methyltransferase 3 [N508S] |
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| Synonyms: | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3) |
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| Type: | Protein |
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| Mol. Mass.: | 59859.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60678[N508S] |
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| Residue: | 531 |
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| Sequence: | MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
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| BDBM50431676 |
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| n/a |
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| Name | BDBM50431676 |
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| Synonyms: | CHEMBL2349526 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20BrN5O5S |
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| Mol. Mass. | 462.319 |
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| SMILES | N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Br)c2c(N)ncnc12)C(O)=O |r| |
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| Structure | 
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