| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50432386 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_952806 (CHEMBL2351311) |
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| IC50 | 1200±n/a nM |
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| Citation |  Du, QR; Li, DD; Pi, YZ; Li, JR; Sun, J; Fang, F; Zhong, WQ; Gong, HB; Zhu, HL Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents. Bioorg Med Chem21:2286-97 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35718.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 313 |
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| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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| BDBM50432386 |
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| n/a |
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| Name | BDBM50432386 |
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| Synonyms: | CHEMBL2348563 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N7O3S |
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| Mol. Mass. | 347.352 |
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| SMILES | Cc1ncc(n1CCSc1nnc(o1)-c1cnccc1N)[N+]([O-])=O |
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| Structure | 
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