Reaction Details | |||
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Target | Serine/threonine-protein kinase mTOR | ||
Ligand | BDBM50433029 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_955789 (CHEMBL2379606) | ||
Ki | 7.5±n/a nM | ||
Citation | Cheng, H; Hoffman, JE; Le, PT; Pairish, M; Kania, R; Farrell, W; Bagrodia, S; Yuan, J; Sun, S; Zhang, E; Xiang, C; Dalvie, D; Rahavendran, SV Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series. Bioorg Med Chem Lett23:2787-92 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase mTOR | |||
Name: | Serine/threonine-protein kinase mTOR | ||
Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
Type: | Rapamycin target protein | ||
Mol. Mass.: | 288917.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P42345 | ||
Residue: | 2549 | ||
Sequence: |
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BDBM50433029 | |||
n/a | |||
Name | BDBM50433029 | ||
Synonyms: | CHEMBL2376092 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H22N6O3 | ||
Mol. Mass. | 370.4057 | ||
SMILES | Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCO)c(=O)c(cc12)-c1cn[nH]c1 |r,wD:8.7,11.14,(55.51,-1.14,;55.51,-2.68,;54.18,-3.45,;54.18,-5,;52.85,-5.77,;55.52,-5.77,;56.85,-5,;58.18,-5.78,;58.18,-7.31,;59.51,-8.08,;59.5,-9.63,;58.16,-10.39,;56.83,-9.61,;56.84,-8.08,;58.15,-11.93,;56.81,-12.69,;55.48,-11.91,;59.53,-5.01,;60.86,-5.78,;59.53,-3.45,;58.19,-2.67,;56.85,-3.45,;60.87,-2.69,;62.26,-3.33,;63.3,-2.2,;62.55,-.86,;61.04,-1.17,)| | ||
Structure |