| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
|---|
| Ligand | BDBM50433274 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_957845 (CHEMBL2378958) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Barlind, JG; Buckett, LK; Crosby, SG; Davidsson, Ö; Emtenäs, H; Ertan, A; Jurva, U; Lemurell, M; Gutierrez, PM; Nilsson, K; O'Mahony, G; Petersson, AU; Redzic, A; Wågberg, F; Yuan, ZQ Identification and design of a novel series of MGAT2 inhibitors. Bioorg Med Chem Lett23:2721-6 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 1 |
|---|
| Name: | Diacylglycerol O-acyltransferase 1 |
|---|
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55297.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75907 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
|
|
|
|---|
| BDBM50433274 |
|---|
| n/a |
|---|
| Name | BDBM50433274 |
|---|
| Synonyms: | CHEMBL2376321 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19F2N3O5S |
|---|
| Mol. Mass. | 439.433 |
|---|
| SMILES | CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(OC(F)F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
