| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase |
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| Ligand | BDBM50433360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956104 (CHEMBL2379168) |
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| IC50 | 11000±n/a nM |
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| Citation |  Lange, S; Keller, M; Müller, C; Oliaro-Bosso, S; Balliano, G; Bracher, F Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors. Eur J Med Chem63:758-64 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase |
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| Name: | Lanosterol synthase |
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| Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | ERG7 | ERG7_PNECA | OSC | Oxidosqualene--lanosterol cyclase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83314.91 |
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| Organism: | Pneumocystis carinii |
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| Description: | ChEMBL_956104 |
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| Residue: | 719 |
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| Sequence: | MIYGYTEKELEKTDPDGWRLIVEDTGRQRWKYLKTEEERRERPQTYMEKYFLGKNMDLPE
QPAAKTPIESARKGFSFYKHLQTSDGNWACEYGGVMFLLPGLIIAMYISKIEFPDEMRIE
VIRYLVNHANPEDGGWGIHIEGKSTVFGTALNYVVLRILGLGPDHPVTMKARIRLNELGG
AIGCPQWGKFWLAVLNCYGWEGINPILPEFWMLPEWLPIHPSRWWVHTRAVYLPMGYIYG
EKFTAPVDPLIESLREELYTQPYSSINFSKHRNTTSPVDVYVPHTRFLRVINSILTFYHT
IFRFSWIKDMASKYAYKLIEYENKNTDFLCIGPVNFSIHILAVYWKEGPDSYAFKSHKER
MADFLWISKKGMMMNGTNGVQLWDTSFAVQALVESGLAEDPEFKDHMIKALDFLDKCQIQ
KNCDDQQKCYRHRRKGAWPFSTRQQGYTVSDCTAEALKAVLLLQNLKSFPKRVSYDRLKD
SVDVILSLQNKDGGFASYELIRGPSWLEFINPAEVFGDIMIEHSYPECTTAAVTALCYFR
SLCSHYRGPEINKSVKNAIQFIKESQRPDGSWYESWAICFTYATMFALESLSCVKDFYEN
SFHSRRACDFLVNKQEEDGGWSEGYQSCTDGIWTRHPTGSQVVQTAWACIGLMYANYPDE
TPIKRGINLIMSRQQPNGEWKQEAIEGVFNKNCMISYPNYKFNFTIKALGMYSKRYGNI
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| BDBM50433360 |
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| n/a |
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| Name | BDBM50433360 |
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| Synonyms: | CHEMBL2375380 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H42N |
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| Mol. Mass. | 368.6178 |
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| SMILES | CC(C)CCC[C@@H](C)[C@H]1CCC2=C(CCC[n+]3ccccc3)CCC[C@]12C |r,c:11| |
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| Structure | 
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