| Reaction Details |
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 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
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| Ligand | BDBM50434482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_961459 (CHEMBL2388171) |
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| Kd | 2360±n/a nM |
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| Citation |  Matsumura, K; Ono, M; Yoshimura, M; Kimura, H; Watanabe, H; Okamoto, Y; Ihara, M; Takahashi, R; Saji, H Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease. Bioorg Med Chem21:3356-62 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Microtubule-associated protein tau |
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| Name: | Microtubule-associated protein tau |
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| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
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| Type: | Protein |
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| Mol. Mass.: | 78928.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10636 |
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| Residue: | 758 |
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| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
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| BDBM50434482 |
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| n/a |
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| Name | BDBM50434482 |
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| Synonyms: | CHEMBL2385163 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12IN3 |
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| Mol. Mass. | 361.1804 |
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| SMILES | Nc1ccc(C=Cc2nc3ccc(I)cc3[nH]2)cc1 |w:6.6| |
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| Structure | 
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