| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Membrane primary amine oxidase |
|---|
| Ligand | BDBM7960 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_965191 (CHEMBL2393976) |
|---|
| IC50 | 4100±n/a nM |
|---|
| Citation |  Inoue, T; Morita, M; Tojo, T; Nagashima, A; Moritomo, A; Miyake, H Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment. Bioorg Med Chem21:3873-81 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Membrane primary amine oxidase |
|---|
| Name: | Membrane primary amine oxidase |
|---|
| Synonyms: | AOC3 | AOC3_HUMAN | Amine oxidase, copper containing | Semicarbazide-sensitive amine oxidase (SSAO) | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | VAP1 | Vascular adhesion protein 1 (VAP-1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 84620.86 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16853 |
|---|
| Residue: | 763 |
|---|
| Sequence: | MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
|
|
|
|---|
| BDBM7960 |
|---|
| n/a |
|---|
| Name | BDBM7960 |
|---|
| Synonyms: | 1H-1,3-benzodiazol-2-amine | 2-Aminobenzimidazole | CHEMBL305513 | CRA Fragment 9 | Imidazole C-2 deriv. 3 | JMC524454 Compound 5 | US11584714, Compound 46 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H7N3 |
|---|
| Mol. Mass. | 133.1506 |
|---|
| SMILES | Nc1nc2ccccc2[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
