Reaction Details |
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Target | Membrane primary amine oxidase |
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Ligand | BDBM50435707 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_965189 (CHEMBL2393850) |
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IC50 | 150±n/a nM |
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Citation | Inoue, T; Morita, M; Tojo, T; Nagashima, A; Moritomo, A; Miyake, H Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment. Bioorg Med Chem21:3873-81 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Membrane primary amine oxidase |
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Name: | Membrane primary amine oxidase |
Synonyms: | AOC3_RAT | Amine oxidase, copper containing | Aoc3 | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | Vascular adhesion protein 1 (VAP-1) |
Type: | Enzyme |
Mol. Mass.: | 84979.78 |
Organism: | Rattus norvegicus (Rat) |
Description: | O08590 |
Residue: | 763 |
Sequence: | MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPF
ADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPP
VREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQ
EMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYP
HPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSW
SLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVA
YEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQ
TPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFH
SNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAW
AEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHR
RGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDF
TDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSP
DSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK
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BDBM50435707 |
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n/a |
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Name | BDBM50435707 |
Synonyms: | CHEMBL2392120 |
Type | Small organic molecule |
Emp. Form. | C16H17N5OS |
Mol. Mass. | 327.404 |
SMILES | CC(=O)Nc1nc(CCc2ccc(cc2)-c2c[nH]c(N)n2)cs1 |
Structure |
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