| Reaction Details |
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 | Report a problem with these data |
| Target | RocR |
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| Ligand | BDBM50436160 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_967469 (CHEMBL2401356) |
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| IC50 | 6410±n/a nM |
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| Citation |  Zhou, J; Watt, S; Wang, J; Nakayama, S; Sayre, DA; Lam, YF; Lee, VT; Sintim, HO Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP. Bioorg Med Chem21:4396-404 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RocR |
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| Name: | RocR |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42828.48 |
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| Organism: | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
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| Description: | ChEMBL_107616 |
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| Residue: | 392 |
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| Sequence: | MNDLNVLVLEDEPFQRLVAVTALKKVVPGSILEAADGKEAVAILESCGHVDIAICDLQMS
GMDGLAFLRHASLSGKVHSVILSSEVDPILRQATISMIECLGLNFLGDLGKPFSLERITA
LLTRYNARRQDLPRQIEVAELPSVADVVRGLDNGEFEAYYQPKVALDGGGLIGAEVLARW
NHPHLGVLPPSHFLYVMETYNLVDKLFWQLFSQGLATRRKLAQLGQPINLAFNVHPSQLG
SRALAENISALLTEFHLPPSSVMFEITETGLISAPASSLENLVRLRIMGCGLAMDDFGAG
YSSLDRLCEFPFSQIKLDRTFVQKMKTQPRSCAVISSVVALAQALGISLVVEGVESDEQR
VRLIELGCSIAQGYLFARPMPEQHFLDYCSGS
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| BDBM50436160 |
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| n/a |
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| Name | BDBM50436160 |
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| Synonyms: | CHEMBL2398347 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28N10O14P2 |
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| Mol. Mass. | 718.4638 |
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| SMILES | CO[C@@H]1[C@@H]2OP(O)(=O)OC[C@H]3O[C@H]([C@H](OC)[C@@H]3OP(O)(=O)OC[C@H]2O[C@H]1n1cnc2c1nc(N)[nH]c2=O)n1cnc2c1nc(N)[nH]c2=O |r| |
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| Structure | 
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