Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 1

Ligand

BDBM50436465

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_967923 (CHEMBL2400739)

IC50

>10000±n/a nM

Citation

Luo, G; Chen, L; Hu, S; Huang, Y; Mattson, G; Iben, LG; Russell, JW; Clarke, WJ; Hogan, JB; Antal-Zimanyi, I; Poindexter, GS Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Bioorg Med Chem Lett23:3814-7 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 1

Name:

Neuropeptide Y receptor type 1

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44399.07

Organism:

Homo sapiens (Human)

Description:

NPY-Y1 NPY1R HUMAN::P25929

Residue:

384

Sequence:

MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI

BDBM50436465

n/a

Name

BDBM50436465

Synonyms:

CHEMBL2397292

Type

Small organic molecule

Emp. Form.

C25H33N3O

Mol. Mass.

391.549

SMILES

CCOc1cccc(c1)C1(C2CC(C)CC12)N1CCN(CC1)c1ccccc1N |(71.32,-17.42,;69.83,-17.03,;68.74,-18.13,;67.25,-17.74,;66.85,-16.24,;65.34,-15.85,;64.26,-16.95,;64.67,-18.44,;66.17,-18.84,;63.58,-19.54,;62.08,-19.85,;60.54,-19.86,;60.07,-18.4,;58.6,-17.92,;61.31,-17.49,;62.56,-18.4,;63.98,-21.02,;62.89,-22.1,;63.28,-23.58,;64.76,-23.99,;65.85,-22.9,;65.46,-21.41,;65.15,-25.47,;64.06,-26.55,;64.45,-28.04,;65.93,-28.45,;67.03,-27.35,;66.63,-25.87,;67.72,-24.78,)|

Structure