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TargetPhosphatidylinositol 4-kinase beta
LigandBDBM50005011
Substrate/Competitorn/a
Meas. Tech.ChEMBL_966466
IC50 100±n/a nM
Citation Décor AGrand-Maître CHucke OO'Meara JKuhn CConstantineau-Forget LBrochu CMalenfant EBertrand-Laperle MBordeleau JGhiro EPesant MFazal GGorys VLittle MBoucher CBordeleau STurcotte PGuo TGarneau MSpickler CGauthier A Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus. Bioorg Med Chem Lett 23:3841-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphatidylinositol 4-kinase beta
Name:Phosphatidylinositol 4-kinase beta
Synonyms:NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta
Type:Protein
Mol. Mass.:91373.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
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  Blast E-value cutoff:
BDBM50005011
n/a
NameBDBM50005011
Synonyms:CHEMBL2397303
TypeSmall organic molecule
Emp. Form.C24H21N5O2S
Mol. Mass.443.521
SMILESNc1ccc(cc1)-c1cnc(NC(=O)CN(Cc2ccccc2)C(=O)c2ccncc2)s1
Structure
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