Reaction Details | |||
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Target | Metabotropic glutamate receptor 1 | ||
Ligand | BDBM50436496 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_966646 (CHEMBL2399851) | ||
IC50 | 3610±n/a nM | ||
Citation | Lovell, KM; Felts, AS; Rodriguez, AL; Venable, DF; Cho, HP; Morrison, RD; Byers, FW; Daniels, JS; Niswender, CM; Conn, PJ; Lindsley, CW; Emmitte, KA N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett23:3713-8 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 1 | |||
Name: | Metabotropic glutamate receptor 1 | ||
Synonyms: | GPRC1A | GRM1 | GRM1_HUMAN | MGLUR1 | Metabotropic Glutamate 1a | metabotropic glutamate 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 132358.19 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13255 | ||
Residue: | 1194 | ||
Sequence: |
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BDBM50436496 | |||
n/a | |||
Name | BDBM50436496 | ||
Synonyms: | CHEMBL2397364 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H33N3O | ||
Mol. Mass. | 343.5062 | ||
SMILES | C[C@@H]1CN(CCN1C(=O)[C@H]1CC[C@@H](CC1)C(C)(C)C)c1ccccn1 |r,wU:9.9,wD:1.0,12.16,(48.62,-41.8,;48.62,-43.34,;49.95,-44.12,;49.95,-45.66,;48.62,-46.42,;47.29,-45.66,;47.29,-44.11,;45.95,-43.35,;45.93,-41.81,;44.62,-44.13,;44.64,-45.67,;43.3,-46.44,;41.96,-45.68,;41.96,-44.14,;43.28,-43.37,;40.63,-46.46,;39.29,-45.69,;40.64,-48,;39.29,-47.22,;51.27,-46.43,;51.27,-47.97,;52.6,-48.75,;53.94,-47.98,;53.93,-46.43,;52.6,-45.66,)| | ||
Structure |