| Reaction Details |
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 | Report a problem with these data |
| Target | Replication protein A 70 kDa DNA-binding subunit |
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| Ligand | BDBM50437299 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972453 (CHEMBL2412823) |
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| Kd | 92000±n/a nM |
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| Citation |  Patrone, JD; Kennedy, JP; Frank, AO; Feldkamp, MD; Vangamudi, B; Pelz, NF; Rossanese, OW; Waterson, AG; Chazin, WJ; Fesik, SW Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med Chem Lett4:601-605 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Replication protein A 70 kDa DNA-binding subunit |
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| Name: | Replication protein A 70 kDa DNA-binding subunit |
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| Synonyms: | REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 68139.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27694 |
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| Residue: | 616 |
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| Sequence: | MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
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| BDBM50437299 |
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| n/a |
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| Name | BDBM50437299 |
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| Synonyms: | CHEMBL2407459 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12ClN3O2S2 |
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| Mol. Mass. | 401.89 |
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| SMILES | Cc1ccc(cc1)-c1n[nH]c(=S)n1-c1ccc2c(Cl)c(sc2c1)C(O)=O |
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| Structure | 
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