Reaction Details |
| Report a problem with these data |
Target | 11-beta-hydroxysteroid dehydrogenase 1 |
---|
Ligand | BDBM50438062 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_972968 (CHEMBL2412206) |
---|
IC50 | >2250±n/a nM |
---|
Citation | Böhme, T; Engel, CK; Farjot, G; Güssregen, S; Haack, T; Tschank, G; Ritter, K 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes. Bioorg Med Chem Lett23:4685-91 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
11-beta-hydroxysteroid dehydrogenase 1 |
---|
Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
|
|
|
BDBM50438062 |
---|
n/a |
---|
Name | BDBM50438062 |
Synonyms: | CHEMBL2409739 |
Type | Small organic molecule |
Emp. Form. | C13H23N3O3S |
Mol. Mass. | 301.405 |
SMILES | CN1CC[C@@H]2OC(NS(=O)(=O)[C@@H]2C1)=NC1CCCCC1 |r,w:13.15| |
Structure |
|