| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Ligand | BDBM34671 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_978866 (CHEMBL2423657) |
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| IC50 | >200000±n/a nM |
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| Citation |  Raoof, A; Depledge, P; Hamilton, NM; Hamilton, NS; Hitchin, JR; Hopkins, GV; Jordan, AM; Maguire, LA; McGonagle, AE; Mould, DP; Rushbrooke, M; Small, HF; Smith, KM; Thomson, GJ; Turlais, F; Waddell, ID; Waszkowycz, B; Watson, AJ; Ogilvie, DJ Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II. J Med Chem56:6352-70 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA-(apurinic or apyrimidinic site) endonuclease |
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| Name: | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Synonyms: | APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1 |
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| Type: | Protein |
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| Mol. Mass.: | 35560.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27695 |
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| Residue: | 318 |
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| Sequence: | MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
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| BDBM34671 |
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| n/a |
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| Name | BDBM34671 |
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| Synonyms: | 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone | MLS000528498 | SMR000121073 | US9073941, 611 | cid_460747 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H9N5O2 |
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| Mol. Mass. | 207.1894 |
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| SMILES | Cc1nn(C)c2nc(=O)n(C)c(=O)c2n1 |
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| Structure | 
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