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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosyl-DNA phosphodiesterase 2 | ||
| Ligand | BDBM50438849 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_978867 (CHEMBL2423658) | ||
| EC50 | 370±n/a nM | ||
| Citation |  Raoof, A; Depledge, P; Hamilton, NM; Hamilton, NS; Hitchin, JR; Hopkins, GV; Jordan, AM; Maguire, LA; McGonagle, AE; Mould, DP; Rushbrooke, M; Small, HF; Smith, KM; Thomson, GJ; Turlais, F; Waddell, ID; Waszkowycz, B; Watson, AJ; Ogilvie, DJ Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II. J Med Chem56:6352-70 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosyl-DNA phosphodiesterase 2 | |||
| Name: | Tyrosyl-DNA phosphodiesterase 2 | ||
| Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 40916.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_23510348 | ||
| Residue: | 362 | ||
| Sequence: |
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| BDBM50438849 | |||
| n/a | |||
| Name | BDBM50438849 | ||
| Synonyms: | CHEMBL2420479 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H10N6O2 | ||
| Mol. Mass. | 354.3217 | ||
| SMILES | O=c1nc2n(-c3cccc4[nH]ncc34)c3cc(ccc3cc2c(=O)[nH]1)C#N |(2.87,-6.9,;4.21,-6.12,;5.54,-6.89,;6.87,-6.12,;8.2,-6.89,;8.2,-8.43,;6.86,-9.18,;6.86,-10.72,;8.19,-11.49,;9.53,-10.71,;10.99,-11.18,;11.88,-9.94,;10.97,-8.71,;9.52,-9.19,;9.54,-6.12,;10.87,-6.89,;12.21,-6.12,;12.21,-4.58,;10.87,-3.8,;9.54,-4.58,;8.2,-3.8,;6.87,-4.58,;5.54,-3.8,;5.54,-2.26,;4.21,-4.58,;13.54,-6.89,;14.88,-7.67,)| | ||
| Structure | 
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