Reaction Details |
| Report a problem with these data |
Target | Tyrosyl-DNA phosphodiesterase 2 |
---|
Ligand | BDBM50438917 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_978867 (CHEMBL2423658) |
---|
EC50 | 770±n/a nM |
---|
Citation | Raoof, A; Depledge, P; Hamilton, NM; Hamilton, NS; Hitchin, JR; Hopkins, GV; Jordan, AM; Maguire, LA; McGonagle, AE; Mould, DP; Rushbrooke, M; Small, HF; Smith, KM; Thomson, GJ; Turlais, F; Waddell, ID; Waszkowycz, B; Watson, AJ; Ogilvie, DJ Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II. J Med Chem56:6352-70 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosyl-DNA phosphodiesterase 2 |
---|
Name: | Tyrosyl-DNA phosphodiesterase 2 |
Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40916.54 |
Organism: | Homo sapiens (Human) |
Description: | gi_23510348 |
Residue: | 362 |
Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
|
|
|
BDBM50438917 |
---|
n/a |
---|
Name | BDBM50438917 |
Synonyms: | CHEMBL2420611 |
Type | Small organic molecule |
Emp. Form. | C10H8N6O2S |
Mol. Mass. | 276.275 |
SMILES | Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1cscn1 |
Structure |
|