| Reaction Details |
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 | Report a problem with these data |
| Target | Short transient receptor potential channel 3 |
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| Ligand | BDBM50439218 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_978642 (CHEMBL2422305) |
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| IC50 | 32±n/a nM |
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| Citation |  Washburn, DG; Holt, DA; Dodson, J; McAtee, JJ; Terrell, LR; Barton, L; Manns, S; Waszkiewicz, A; Pritchard, C; Gillie, DJ; Morrow, DM; Davenport, EA; Lozinskaya, IM; Guss, J; Basilla, JB; Negron, LK; Klein, M; Willette, RN; Fries, RE; Jensen, TC; Xu, X; Schnackenberg, CG; Marino, JP The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett23:4979-84 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Short transient receptor potential channel 3 |
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| Name: | Short transient receptor potential channel 3 |
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| Synonyms: | TRP-3 | TRP3 | TRPC3 | TRPC3_HUMAN | Transient receptor protein 3 | hTrp-3 | hTrp3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96009.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107641 |
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| Residue: | 836 |
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| Sequence: | MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY
MGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKR
LTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDY
FCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIE
KEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLA
IKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPC
SRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTT
QFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFL
QATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSR
IAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT
TVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINS
SYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRR
RLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQV
DKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
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| BDBM50439218 |
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| n/a |
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| Name | BDBM50439218 |
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| Synonyms: | CHEMBL2418809 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19ClFN3O3S |
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| Mol. Mass. | 411.878 |
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| SMILES | CC1CCCN(C1C)C(=O)c1nc(Nc2cc3OCOc3cc2F)sc1Cl |
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| Structure | 
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