| Reaction Details |
|---|
 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
|---|
| Ligand | BDBM50439493 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_979064 (CHEMBL2421323) |
|---|
| IC50 | 350±n/a nM |
|---|
| Citation |  Asano, M; Hashimoto, K; Saito, B; Shiokawa, Z; Sumi, H; Yabuki, M; Yoshimatsu, M; Aoyama, K; Hamada, T; Morishita, N; Dougan, DR; Mol, CD; Yoshida, S; Ishikawa, T Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists. Bioorg Med Chem21:5725-37 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| E3 ubiquitin-protein ligase XIAP |
|---|
| Name: | E3 ubiquitin-protein ligase XIAP |
|---|
| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56685.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P98170 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
|
|
|
|---|
| BDBM50439493 |
|---|
| n/a |
|---|
| Name | BDBM50439493 |
|---|
| Synonyms: | CHEMBL2417929 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H43N5O4 |
|---|
| Mol. Mass. | 537.6935 |
|---|
| SMILES | CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H]2C[C@@H]3C[C@@H]3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
