Reaction Details |
| Report a problem with these data |
Target | N-acylethanolamine-hydrolyzing acid amidase |
---|
Ligand | BDBM50439664 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_978417 (CHEMBL2421059) |
---|
IC50 | 7.0±n/a nM |
---|
Citation | Ponzano, S; Bertozzi, F; Mengatto, L; Dionisi, M; Armirotti, A; Romeo, E; Berteotti, A; Fiorelli, C; Tarozzo, G; Reggiani, A; Duranti, A; Tarzia, G; Mor, M; Cavalli, A; Piomelli, D; Bandiera, T Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem56:6917-34 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
N-acylethanolamine-hydrolyzing acid amidase |
---|
Name: | N-acylethanolamine-hydrolyzing acid amidase |
Synonyms: | ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa |
Type: | Enzyme |
Mol. Mass.: | 40306.53 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q5KTC7 |
Residue: | 362 |
Sequence: | MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
|
|
|
BDBM50439664 |
---|
n/a |
---|
Name | BDBM50439664 |
Synonyms: | CHEMBL2419814 | US9353075, 17 |
Type | Small organic molecule |
Emp. Form. | C18H17NO4 |
Mol. Mass. | 311.3319 |
SMILES | C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1 |r| |
Structure |
|