| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 10 |
|---|
| Ligand | BDBM50441212 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_984236 (CHEMBL2432396) |
|---|
| IC50 | 150±n/a nM |
|---|
| Citation |  Nuti, E; Casalini, F; Santamaria, S; Fabbi, M; Carbotti, G; Ferrini, S; Marinelli, L; La Pietra, V; Novellino, E; Camodeca, C; Orlandini, E; Nencetti, S; Rossello, A Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models. J Med Chem56:8089-103 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Disintegrin and metalloproteinase domain-containing protein 10 |
|---|
| Name: | Disintegrin and metalloproteinase domain-containing protein 10 |
|---|
| Synonyms: | ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 84160.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14672 |
|---|
| Residue: | 748 |
|---|
| Sequence: | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
|
|
|
|---|
| BDBM50441212 |
|---|
| n/a |
|---|
| Name | BDBM50441212 |
|---|
| Synonyms: | CHEMBL2431028 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22Br2N4O6S |
|---|
| Mol. Mass. | 594.274 |
|---|
| SMILES | NC(=O)NCCC[C@@H](NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1)C(=O)NO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
