Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM24400
Substrate/Competitorn/a
Meas. Tech.ChEMBL_984625 (CHEMBL2434280)
IC50 31±n/a nM
Citation Xu, M; Zhu, J; Diao, Y; Zhou, H; Ren, X; Sun, D; Huang, J; Han, D; Zhao, Z; Zhu, L; Xu, Y; Li, H Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem56:7911-24 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase
Type:Enzyme
Mol. Mass.:65581.88
Organism:Plasmodium falciparum
Description:His6-tag DHODH was expressed in E. coli.
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM24400
n/a
NameBDBM24400
Synonyms:5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | JMC521864 Compund DSM1 | Triazolopyrimidine-Based Compound, 7
TypeSmall organic molecule
Emp. Form.C16H13N5
Mol. Mass.275.3079
SMILESCc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: