| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
|---|
| Ligand | BDBM50441474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_988348 (CHEMBL2437611) |
|---|
| IC50 | 228±n/a nM |
|---|
| Citation |  Kato, Y; Fuchi, N; Saburi, H; Nishimura, Y; Watanabe, A; Yagi, M; Nakadera, Y; Higashi, E; Yamada, M; Aoki, T Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension. Bioorg Med Chem Lett23:5975-9 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional epoxide hydrolase 2 |
|---|
| Name: | Bifunctional epoxide hydrolase 2 |
|---|
| Synonyms: | Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62512.06 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P34914 |
|---|
| Residue: | 554 |
|---|
| Sequence: | MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF
SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC
IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYV
TVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPF
MPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHK
ATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLG
RKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKW
LQTEVQNPSVTSKI
|
|
|
|---|
| BDBM50441474 |
|---|
| n/a |
|---|
| Name | BDBM50441474 |
|---|
| Synonyms: | CHEMBL2436563 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22F5N3O2 |
|---|
| Mol. Mass. | 467.4317 |
|---|
| SMILES | Fc1cccc(F)c1C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(cc2)C(F)(F)F)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
