| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50441509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_988451 (CHEMBL2437993) |
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| Ki | 3.0±n/a nM |
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| Citation |  de Lera Ruiz, M; Zheng, J; Berlin, MY; McCormick, KD; Aslanian, RG; West, R; Hwa, J; Lachowicz, J; van Heek, M Bicyclic and tricyclic heterocycle derivatives as histamine H3 receptor antagonists for the treatment of obesity. Bioorg Med Chem Lett23:6004-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_MOUSE | Hrh3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48560.37 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_988451 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50441509 |
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| n/a |
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| Name | BDBM50441509 |
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| Synonyms: | CHEMBL2436622 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36FN5O |
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| Mol. Mass. | 465.606 |
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| SMILES | Nc1cc(CN2CCC(F)(CC2)C(=O)N2CCC(CC2)N2CCc3ccccc3CC2)ccn1 |
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| Structure | 
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