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TargetNeuropeptide Y receptor type 4
LigandBDBM50441954
Substrate/Competitorn/a
Meas. Tech.ChEMBL_992059 (CHEMBL2447702)
Ki 157±n/a nM
Citation Berlicki, L; Kaske, M; Gutièrrez-Abad, R; Bernhardt, G; Illa, O; Ortuno, RM; Cabrele, C; Buschauer, A; Reiser, O Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane and cis-cyclopentane β-amino acids shifts selectivity toward the Y(4) receptor. J Med Chem56:8422-31 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuropeptide Y receptor type 4
Name:Neuropeptide Y receptor type 4
Synonyms:NPY-Y4 | NPY4-R | NPY4R | NPY4R_HUMAN | PP1 | PPYR1 | Pancreatic polypeptide receptor 1
Type:Enzyme Catalytic Domain
Mol. Mass.:42207.58
Organism:Homo sapiens (Human)
Description:NPY-Y4 PPYR1 HUMAN::P50391
Residue:375
Sequence:
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL
CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI
QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL
ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR
LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHG
NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE
VSKGSLRLSGRSNPI
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  Blast E-value cutoff:
BDBM50441954
n/a
NameBDBM50441954
Synonyms:CHEMBL2440186
TypeSmall organic molecule
Emp. Form.C76H123N25O17
Mol. Mass.1658.9471
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:30.39,8.17,2.2,45.46,61.62,76.77,95.96,wD:20.28,4.4,53.54,62.64,69.70,70.73,87.88,106.107,(14.44,-25.37,;14.44,-23.83,;15.77,-23.06,;17.11,-23.83,;15.77,-21.52,;14.44,-20.75,;13.11,-21.52,;13.11,-23.06,;11.77,-20.75,;11.77,-19.21,;13.11,-18.44,;14.42,-19.22,;15.77,-18.45,;15.77,-16.9,;17.11,-16.13,;14.42,-16.14,;13.11,-16.91,;10.44,-21.52,;9.1,-20.75,;9.1,-19.21,;7.77,-21.52,;7.77,-23.06,;9.1,-23.83,;10.52,-23.21,;11.55,-24.35,;10.78,-25.69,;9.27,-25.37,;6.44,-20.75,;5.1,-21.52,;5.1,-23.06,;3.77,-20.75,;3.77,-19.21,;5.1,-18.44,;5.1,-16.9,;6.44,-16.13,;6.44,-14.59,;5.1,-13.82,;7.77,-13.82,;2.43,-21.52,;1.11,-20.75,;-.23,-21.52,;1.11,-19.21,;17.11,-20.75,;17.11,-19.21,;18.44,-21.52,;19.77,-20.75,;19.77,-19.21,;21.11,-18.44,;22.44,-19.21,;21.11,-16.9,;21.11,-21.52,;21.11,-23.06,;22.44,-20.75,;23.78,-21.52,;23.78,-23.06,;25.11,-23.83,;25.11,-25.37,;26.44,-23.06,;25.11,-20.75,;25.11,-19.21,;26.44,-21.52,;27.78,-20.75,;27.78,-19.21,;29.11,-18.44,;26.44,-18.44,;26.44,-16.9,;29.11,-21.52,;29.11,-23.06,;30.45,-20.75,;31.78,-21.52,;31.78,-23.06,;30.45,-23.83,;33.11,-23.83,;33.11,-20.75,;33.11,-19.21,;34.45,-21.52,;35.78,-20.75,;35.78,-19.21,;37.11,-18.44,;37.11,-16.9,;38.44,-16.13,;38.44,-14.59,;37.11,-13.82,;39.78,-13.82,;37.11,-21.52,;37.11,-23.06,;38.44,-20.75,;39.78,-21.52,;39.78,-23.06,;41.11,-23.83,;41.11,-25.37,;42.45,-23.06,;41.11,-20.75,;41.11,-19.21,;42.45,-21.52,;43.78,-20.75,;43.78,-19.21,;45.11,-18.44,;45.11,-16.9,;46.45,-16.13,;46.45,-14.59,;45.11,-13.82,;47.78,-13.82,;45.11,-21.52,;45.11,-23.06,;46.45,-20.75,;47.78,-21.52,;47.78,-23.06,;49.12,-23.83,;50.45,-23.06,;51.78,-23.83,;51.78,-25.37,;53.12,-26.14,;50.45,-26.14,;49.12,-25.37,;49.12,-20.75,;50.45,-21.52,;49.12,-19.21,)|
Structure
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