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TargetHistamine H1 receptor
LigandBDBM50442179
Substrate/Competitorn/a
Meas. Tech.ChEMBL_991510 (CHEMBL2445021)
Ki 399±n/a nM
Citation Aristotelous, TAhn, SShukla, AKGawron, SSassano, MFKahsai, AWWingler, LMZhu, XTripathi-Shukla, PHuang, XPRiley, JBesnard, JRead, KDRoth, BLGilbert, IHHopkins, ALLefkowitz, RJNavratilova, I Discovery of?2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. ACS Med Chem Lett4:1005-1010 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H1 receptor
Name:Histamine H1 receptor
Synonyms:H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:55808.72
Organism:Homo sapiens (Human)
Description:Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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  Blast E-value cutoff:
BDBM50442179
n/a
NameBDBM50442179
Synonyms:CHEMBL2441619
TypeSmall organic molecule
Emp. Form.C15H16F3N3
Mol. Mass.295.3028
SMILESCc1ccc2nc(cc(N3CCNCC3)c2c1)C(F)(F)F
Structure
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