| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
|---|
| Ligand | BDBM50442324 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_993410 (CHEMBL2444879) |
|---|
| IC50 | 960±n/a nM |
|---|
| Citation |  Ferlin, MG; Carta, D; Bortolozzi, R; Ghodsi, R; Chimento, A; Pezzi, V; Moro, S; Hanke, N; Hartmann, RW; Basso, G; Viola, G Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors. J Med Chem56:7536-51 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B1, mitochondrial |
|---|
| Name: | Cytochrome P450 11B1, mitochondrial |
|---|
| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57591.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15538 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
|
|
|
|---|
| BDBM50442324 |
|---|
| n/a |
|---|
| Name | BDBM50442324 |
|---|
| Synonyms: | CHEMBL2442757 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H18N4O |
|---|
| Mol. Mass. | 354.4045 |
|---|
| SMILES | COc1ccc(cc1)-c1cc(Cn2ccnc2)c2ccc3[nH]ccc3c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
