| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Replication protein A 70 kDa DNA-binding subunit |
|---|
| Ligand | BDBM50443304 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1274586 (CHEMBL3091186) |
|---|
| Kd | 580000±n/a nM |
|---|
| Citation |  Frank, AO; Feldkamp, MD; Kennedy, JP; Waterson, AG; Pelz, NF; Patrone, JD; Vangamudi, B; Camper, DV; Rossanese, OW; Chazin, WJ; Fesik, SW Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J Med Chem56:9242-50 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Replication protein A 70 kDa DNA-binding subunit |
|---|
| Name: | Replication protein A 70 kDa DNA-binding subunit |
|---|
| Synonyms: | REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68139.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27694 |
|---|
| Residue: | 616 |
|---|
| Sequence: | MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
|
|
|
|---|
| BDBM50443304 |
|---|
| n/a |
|---|
| Name | BDBM50443304 |
|---|
| Synonyms: | CHEMBL3088227 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14N2O2 |
|---|
| Mol. Mass. | 278.3053 |
|---|
| SMILES | Cc1cccc(c1)-n1nc(cc1-c1ccccc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
