Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50443494 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1275023 (CHEMBL3090781) |
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IC50 | 80±n/a nM |
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Citation | Bavetsias, V; Faisal, A; Crumpler, S; Brown, N; Kosmopoulou, M; Joshi, A; Atrash, B; Pérez-Fuertes, Y; Schmitt, JA; Boxall, KJ; Burke, R; Sun, C; Avery, S; Bush, K; Henley, A; Raynaud, FI; Workman, P; Bayliss, R; Linardopoulos, S; Blagg, J Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. J Med Chem56:9122-35 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50443494 |
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n/a |
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Name | BDBM50443494 |
Synonyms: | CHEMBL3087776 |
Type | Small organic molecule |
Emp. Form. | C17H20ClN7O |
Mol. Mass. | 373.84 |
SMILES | CC(=O)N[C@H]1CCN(C1)c1c(Cl)cnc2nc([nH]c12)-c1cn(C)nc1C |r| |
Structure |
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