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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50444071 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1279519 (CHEMBL3097238) | ||
| IC50 | 3.4±n/a nM | ||
| Citation |  Zhang, W; Zhang, D; Stashko, MA; DeRyckere, D; Hunter, D; Kireev, D; Miley, MJ; Cummings, C; Lee, M; Norris-Drouin, J; Stewart, WM; Sather, S; Zhou, Y; Kirkpatrick, G; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem56:9683-92 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50444071 | |||
| n/a | |||
| Name | BDBM50444071 | ||
| Synonyms: | CHEMBL3092794 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H39N7O2 | ||
| Mol. Mass. | 481.6336 | ||
| SMILES | CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(NC(=O)C2CCN(C)CC2)cn1 |r,wU:11.10,wD:14.14,(41.44,-46.25,;42.77,-45.48,;44.11,-46.25,;45.44,-45.48,;46.77,-46.25,;48.11,-45.48,;49.44,-46.25,;50.78,-45.48,;50.78,-43.93,;49.44,-43.17,;49.44,-41.63,;48.1,-40.86,;46.77,-41.63,;45.44,-40.86,;45.44,-39.32,;44.1,-38.54,;46.77,-38.55,;48.1,-39.31,;48.11,-43.94,;52.11,-43.16,;53.44,-43.93,;54.77,-43.15,;54.76,-41.61,;56.09,-40.83,;57.43,-41.6,;57.44,-43.14,;58.76,-40.82,;60.09,-41.59,;61.42,-40.82,;61.42,-39.28,;62.75,-38.51,;60.08,-38.51,;58.74,-39.29,;53.42,-40.85,;52.09,-41.62,)| | ||
| Structure | 
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