| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatic triacylglycerol lipase |
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| Ligand | BDBM50444138 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1280893 (CHEMBL3095191) |
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| IC50 | 9500±n/a nM |
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| Citation |  Sun, S; Dean, R; Jia, Q; Zenova, A; Zhong, J; Grayson, C; Xie, C; Lindgren, A; Samra, P; Sojo, L; van Heek, M; Lin, L; Percival, D; Fu, JM; Winther, MD; Zhang, Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem21:7724-34 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hepatic triacylglycerol lipase |
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| Name: | Hepatic triacylglycerol lipase |
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| Synonyms: | HL | HTGL | Hepatic Lipase (HL) | Hepatic lipase | Hepatic triacylglycerol lipase | LIPC | LIPC_HUMAN | Lipase member C |
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| Type: | Protein |
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| Mol. Mass.: | 55938.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11150 |
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| Residue: | 499 |
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| Sequence: | MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQ
GCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLV
DWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSS
IGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGH
YDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAY
PCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQF
INQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKW
ENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQ
EKIFVKCEIKSKTSKRKIR
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| BDBM50444138 |
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| n/a |
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| Name | BDBM50444138 |
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| Synonyms: | CHEMBL3093392 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17F3N2O3 |
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| Mol. Mass. | 366.3344 |
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| SMILES | OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ccccn1)C(F)(F)F |r| |
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| Structure | 
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