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TargetLipoprotein lipase
LigandBDBM50444138
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1280894
IC50 20000±n/a nM
Citation Sun SDean RJia QZenova AZhong JGrayson CXie CLindgren ASamra PSojo Lvan Heek MLin LPercival DFu JMWinther MDZhang Z Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem 21:7724-34 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lipoprotein lipase
Name:Lipoprotein lipase
Synonyms:LPL
Type:PROTEIN
Mol. Mass.:53173.96
Organism:Homo sapiens (Human)
Description:ChEMBL_1280894
Residue:475
Sequence:
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGV
AESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEH
YPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRIT
GLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQ
PGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKG
LCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQ
AFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDW
WSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50444138
n/a
NameBDBM50444138
Synonyms:CHEMBL3093392
TypeSmall organic molecule
Emp. Form.C18H17F3N2O3
Mol. Mass.366.3344
SMILESOC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ccccn1)C(F)(F)F |r|
Structure
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