Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase receptor UFO

Ligand

BDBM50444261

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1277931 (CHEMBL3094775)

IC50

>30000±n/a nM

Citation

Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor UFO

Name:

Tyrosine-protein kinase receptor UFO

Synonyms:

Type:

Enzyme

Mol. Mass.:

98316.97

Organism:

Homo sapiens (Human)

Description:

P30530

Residue:

894

Sequence:

MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA

BDBM50444261

n/a

Name

BDBM50444261

Synonyms:

CHEMBL3093765

Type

Small organic molecule

Emp. Form.

C22H31FN6O

Mol. Mass.

414.5195

SMILES

CCCCNc1ncc(NC(=O)c2ccc(F)cc2)c(NC[C@H]2CC[C@H](N)CC2)n1 |r,wU:22.22,wD:25.26,(18,-11.88,;19.34,-11.11,;20.67,-11.89,;22.01,-11.12,;23.34,-11.89,;24.67,-11.12,;26.01,-11.89,;27.35,-11.12,;27.34,-9.57,;28.67,-8.79,;30.01,-9.56,;30.01,-11.1,;31.34,-8.78,;32.67,-9.55,;34,-8.78,;34,-7.24,;35.33,-6.46,;32.65,-6.47,;31.33,-7.25,;26,-8.8,;26,-7.26,;24.66,-6.5,;24.66,-4.96,;23.33,-4.2,;23.33,-2.65,;24.67,-1.88,;24.67,-.34,;26,-2.65,;26,-4.19,;24.68,-9.57,)|

Structure