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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50444274 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1277932 (CHEMBL3094776) | ||
| IC50 | 37±n/a nM | ||
| Citation |  Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50444274 | |||
| n/a | |||
| Name | BDBM50444274 | ||
| Synonyms: | CHEMBL3093647 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H32N6O5S | ||
| Mol. Mass. | 504.602 | ||
| SMILES | CCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:27.28,wD:30.32,(50.31,-10.83,;51.65,-10.06,;52.98,-10.83,;54.31,-10.06,;55.65,-10.83,;56.98,-10.06,;56.98,-8.51,;58.31,-7.73,;58.3,-6.19,;59.65,-8.5,;60.98,-7.72,;62.31,-8.5,;63.64,-7.72,;63.64,-6.18,;62.29,-5.42,;60.97,-6.19,;64.96,-5.4,;64.19,-4.06,;65.73,-4.06,;66.3,-6.17,;66.3,-7.7,;67.63,-8.46,;68.96,-7.69,;68.96,-6.15,;67.62,-5.38,;55.64,-7.75,;55.64,-6.21,;54.3,-5.44,;52.98,-6.21,;51.64,-5.44,;51.64,-3.89,;50.31,-3.12,;52.98,-3.13,;54.3,-3.89,;54.31,-8.52,)| | ||
| Structure | 
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