Reaction Details | |||
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Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM50444240 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1277932 (CHEMBL3094776) | ||
IC50 | 2.1±n/a nM | ||
Citation | Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM50444240 | |||
n/a | |||
Name | BDBM50444240 | ||
Synonyms: | CHEMBL3093635 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H37N7O4S | ||
Mol. Mass. | 531.671 | ||
SMILES | CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](N)CC2)n1 |r,wU:29.30,wD:32.34,(.04,-21.39,;1.37,-20.63,;2.71,-21.4,;4.04,-20.63,;5.37,-21.4,;6.71,-20.63,;8.04,-21.4,;9.38,-20.63,;9.37,-19.08,;10.7,-18.3,;10.7,-16.76,;12.04,-19.07,;13.37,-18.29,;14.71,-19.07,;16.03,-18.29,;16.03,-16.75,;14.68,-15.99,;13.36,-16.76,;17.36,-15.97,;16.58,-14.63,;18.13,-14.62,;18.7,-16.74,;18.69,-18.27,;20.02,-19.03,;21.36,-18.26,;21.35,-16.72,;20.01,-15.95,;8.04,-18.32,;8.03,-16.78,;6.7,-16.01,;5.36,-16.79,;4.03,-16.01,;4.03,-14.47,;2.69,-13.7,;5.36,-13.71,;6.69,-14.47,;6.71,-19.09,)| | ||
Structure |