Reaction Details | |||
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Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM50444244 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1277932 (CHEMBL3094776) | ||
IC50 | 6.3±n/a nM | ||
Citation | Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM50444244 | |||
n/a | |||
Name | BDBM50444244 | ||
Synonyms: | CHEMBL3093753 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H36N6O5S | ||
Mol. Mass. | 532.656 | ||
SMILES | CCCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:29.30,wD:32.34,(46.77,-58.29,;48.1,-57.52,;49.43,-58.29,;50.77,-57.52,;52.1,-58.3,;53.43,-57.53,;54.77,-58.3,;56.11,-57.53,;56.1,-55.98,;57.43,-55.2,;57.43,-53.66,;58.77,-55.97,;60.1,-55.19,;61.43,-55.96,;62.76,-55.19,;62.76,-53.65,;61.41,-52.88,;60.09,-53.66,;64.09,-52.87,;64.85,-51.53,;63.31,-51.54,;65.42,-53.63,;65.42,-55.17,;66.75,-55.93,;68.08,-55.16,;68.08,-53.62,;66.74,-52.85,;54.76,-55.21,;54.76,-53.67,;53.42,-52.91,;52.09,-53.69,;50.75,-52.91,;50.75,-51.37,;49.42,-50.6,;52.09,-50.6,;53.42,-51.37,;53.44,-55.98,)| | ||
Structure |