Reaction Details | |||
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Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM50444241 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1277920 (CHEMBL3094764) | ||
IC50 | 22±n/a nM | ||
Citation | Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM50444241 | |||
n/a | |||
Name | BDBM50444241 | ||
Synonyms: | CHEMBL3093756 | US9649309, Compound UNC2881A | ||
Type | Small organic molecule | ||
Emp. Form. | C25H33N7O2 | ||
Mol. Mass. | 463.5752 | ||
SMILES | CCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:26.27,wD:29.31,(48.43,-9.69,;49.77,-8.92,;51.1,-9.69,;52.43,-8.92,;53.77,-9.69,;55.1,-8.93,;56.43,-9.7,;57.77,-8.92,;57.77,-7.37,;59.1,-6.6,;59.09,-5.06,;60.43,-7.36,;61.76,-6.59,;63.1,-7.35,;63.1,-8.89,;64.44,-9.66,;65.77,-8.88,;65.76,-7.33,;64.42,-6.58,;67.11,-9.64,;68.5,-9.01,;69.54,-10.15,;68.78,-11.49,;67.27,-11.18,;56.43,-6.61,;56.43,-5.07,;55.09,-4.3,;53.76,-5.08,;52.42,-4.31,;52.42,-2.77,;51.09,-2,;53.75,-2,;55.08,-2.77,;55.1,-7.38,)| | ||
Structure |