Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase receptor TYRO3 | ||
| Ligand | BDBM50444270 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1277930 (CHEMBL3094774) | ||
| IC50 | 5100±n/a nM | ||
| Citation |  Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase receptor TYRO3 | |||
| Name: | Tyrosine-protein kinase receptor TYRO3 | ||
| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY | ||
| Type: | Protein | ||
| Mol. Mass.: | 96894.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06418 | ||
| Residue: | 890 | ||
| Sequence: |
| ||
| BDBM50444270 | |||
| n/a | |||
| Name | BDBM50444270 | ||
| Synonyms: | CHEMBL3093628 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33F3N6O5S | ||
| Mol. Mass. | 586.627 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)Nc1nc(NCCCC(F)(F)F)ncc1C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wU:4.7,wD:1.0,(4.09,-26.59,;5.43,-27.36,;5.43,-28.9,;6.76,-29.68,;8.09,-28.9,;8.09,-27.36,;6.76,-26.59,;9.43,-29.67,;9.43,-31.21,;8.1,-31.98,;8.1,-33.53,;6.76,-34.29,;5.43,-33.52,;4.1,-34.29,;2.76,-33.52,;1.43,-34.29,;.1,-33.52,;1.43,-35.83,;.09,-35.05,;9.43,-34.3,;10.77,-33.52,;10.77,-31.97,;12.1,-31.2,;12.09,-29.66,;13.43,-31.96,;14.76,-31.19,;16.1,-31.96,;17.43,-31.19,;17.42,-29.64,;16.08,-28.88,;14.75,-29.66,;18.75,-28.86,;17.97,-27.52,;19.52,-27.52,;20.09,-29.63,;20.08,-31.17,;21.41,-31.93,;22.75,-31.16,;22.74,-29.62,;21.41,-28.84,)| | ||
| Structure | 
| ||