Ki Summary

Reaction Details

Report a problem with these data

Target

Tyrosine-protein kinase receptor UFO

Ligand

BDBM50444273

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1277931 (CHEMBL3094775)

IC50

610±n/a nM

Citation

Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor UFO

Name:

Tyrosine-protein kinase receptor UFO

Synonyms:

Type:

Enzyme

Mol. Mass.:

98316.97

Organism:

Homo sapiens (Human)

Description:

P30530

Residue:

894

Sequence:

MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA

BDBM50444273

n/a

Name

BDBM50444273

Synonyms:

CHEMBL3093625

Type

Small organic molecule

Emp. Form.

C24H34N6O5S

Mol. Mass.

518.629

SMILES

CCCNc1ncc(C(=O)Nc2ccc(cc2)S(=O)(=O)N2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:28.29,wD:31.33,(2.34,-21.85,;3.67,-22.62,;5,-21.85,;6.34,-22.62,;7.67,-21.85,;9.01,-22.62,;10.34,-21.85,;10.34,-20.3,;11.67,-19.52,;11.66,-17.98,;13,-20.29,;14.34,-19.51,;15.67,-20.29,;17,-19.51,;16.99,-17.97,;15.65,-17.21,;14.32,-17.98,;18.32,-17.19,;17.55,-15.85,;19.09,-15.85,;19.66,-17.96,;19.66,-19.49,;20.99,-20.25,;22.32,-19.48,;22.32,-17.94,;20.98,-17.17,;9,-19.54,;9,-18,;7.66,-17.23,;6.34,-18,;5,-17.23,;5,-15.69,;3.67,-14.91,;6.33,-14.92,;7.66,-15.68,;7.67,-20.31,)|

Structure