| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
|---|
| Ligand | BDBM50444655 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1281258 (CHEMBL3100993) |
|---|
| IC50 | 0.600000±n/a nM |
|---|
| Citation |  Zheng, X; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Han, B; Ho, YC; Kley, N; Lin, J; Reynolds, DJ; Sharma, G; Smith, CC; Wang, Z; Dragovich, PS; Oh, A; Wang, W; Zak, M; Wang, Y; Yuen, PW; Bair, KW Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg Med Chem Lett24:337-43 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nicotinamide phosphoribosyltransferase |
|---|
| Name: | Nicotinamide phosphoribosyltransferase |
|---|
| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55524.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43490 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
|
|
|
|---|
| BDBM50444655 |
|---|
| n/a |
|---|
| Name | BDBM50444655 |
|---|
| Synonyms: | CHEMBL3098518 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H15F2N5O2S |
|---|
| Mol. Mass. | 427.427 |
|---|
| SMILES | Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(NC#N)=Nc2ccncc2)cc1 |w:21.22| |
|---|
| Structure | 
|
|---|
Search and Browse
