| Reaction Details |
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 | Report a problem with these data |
| Target | Inorganic pyrophosphatase |
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| Ligand | BDBM50444859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1282725 (CHEMBL3101912) |
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| IC50 | 147500±n/a nM |
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| Citation |  Lv, W; Banerjee, B; Molland, KL; Seleem, MN; Ghafoor, A; Hamed, MI; Wan, B; Franzblau, SG; Mesecar, AD; Cushman, M Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase. Bioorg Med Chem22:406-18 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inorganic pyrophosphatase |
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| Name: | Inorganic pyrophosphatase |
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| Synonyms: | IPYR_MYCTU | Inorganic pyrophosphatase | Inorganic pyrophosphatase (MtPPiase) | PPase | Pyrophosphate phospho-hydrolase | ppa |
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| Type: | Protein |
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| Mol. Mass.: | 18318.35 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WI55 |
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| Residue: | 162 |
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| Sequence: | MQFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMAYPTDYGFIEDTLGDDGDPLDALV
LLPQPVFPGVLVAARPVGMFRMVDEHGGDDKVLCVPAGDPRWDHVQDIGDVPAFELDAIK
HFFVHYKDLEPGKFVKAADWVDRAEAEAEVQRSVERFKAGTH
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| BDBM50444859 |
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| n/a |
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| Name | BDBM50444859 |
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| Synonyms: | CHEMBL3099427 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClN4O |
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| Mol. Mass. | 340.807 |
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| SMILES | Cc1ccc(o1)-c1cnnc(n1)N1CCC(C1)c1cccc(Cl)c1 |
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| Structure | 
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