| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50445724 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1284539 (CHEMBL3106734) |
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| IC50 | 90±n/a nM |
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| Citation |  Sun, S; Zhang, Z; Raina, V; Pokrovskaia, N; Hou, D; Namdari, R; Khakh, K; Ratkay, LG; McLaren, DG; Mork, M; Fu, J; Ferreira, S; Hubbard, B; Winther, MD; Dales, N Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects. Bioorg Med Chem Lett24:526-31 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_MOUSE | Scd1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41064.54 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1462109 |
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| Residue: | 355 |
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| Sequence: | MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEG
PPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWS
HRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGW
LLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVN
SLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTF
PFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
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| BDBM50445724 |
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| n/a |
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| Name | BDBM50445724 |
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| Synonyms: | CHEMBL3104391 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N3O3S |
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| Mol. Mass. | 355.411 |
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| SMILES | COc1ccn(-c2nc(C)c(s2)C(=O)NCc2ccccc2)c(=O)c1 |
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| Structure | 
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