Reaction Details |
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Target | Histone deacetylase 3 |
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Ligand | BDBM50245989 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1287886 (CHEMBL3112170) |
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IC50 | 380±n/a nM |
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Citation | Bürli, RW; Luckhurst, CA; Aziz, O; Matthews, KL; Yates, D; Lyons, KA; Beconi, M; McAllister, G; Breccia, P; Stott, AJ; Penrose, SD; Wall, M; Lamers, M; Leonard, P; Müller, I; Richardson, CM; Jarvis, R; Stones, L; Hughes, S; Wishart, G; Haughan, AF; O'Connell, C; Mead, T; McNeil, H; Vann, J; Mangette, J; Maillard, M; Beaumont, V; Munoz-Sanjuan, I; Dominguez, C Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J Med Chem56:9934-54 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 3 |
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Name: | Histone deacetylase 3 |
Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
Type: | Enzyme |
Mol. Mass.: | 48829.55 |
Organism: | Homo sapiens (Human) |
Description: | O15379 |
Residue: | 428 |
Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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BDBM50245989 |
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n/a |
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Name | BDBM50245989 |
Synonyms: | 1-(5-(3-((4-(1,3,4-oxadiazol-2-yl)phenoxy)methyl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)-2,2,2-trifluoroethanone | CHEMBL518821 |
Type | Small organic molecule |
Emp. Form. | C17H9F3N4O4S |
Mol. Mass. | 422.338 |
SMILES | FC(F)(F)C(=O)c1ccc(s1)-c1nc(COc2ccc(cc2)-c2nnco2)no1 |
Structure |
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