| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM51526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1289424 (CHEMBL3116920) |
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| Kd | 12000±n/a nM |
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| Citation |  Dragovich, PS; Zhao, G; Baumeister, T; Bravo, B; Giannetti, AM; Ho, YC; Hua, R; Li, G; Liang, X; Ma, X; O'Brien, T; Oh, A; Skelton, NJ; Wang, C; Wang, W; Wang, Y; Xiao, Y; Yuen, PW; Zak, M; Zhao, Q; Zheng, X Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett24:954-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM51526 |
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| n/a |
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| Name | BDBM51526 |
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| Synonyms: | 6-[(dimethylamino)methyl]-4-ethyl-7-hydroxy-8-methyl-1-benzopyran-2-one | 6-[(dimethylamino)methyl]-4-ethyl-7-hydroxy-8-methyl-coumarin | 6-[(dimethylamino)methyl]-4-ethyl-7-hydroxy-8-methylchromen-2-one | 6-[(dimethylamino)methyl]-4-ethyl-8-methyl-7-oxidanyl-chromen-2-one | MLS000042532 | SMR000048671 | cid_5390086 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19NO3 |
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| Mol. Mass. | 261.3163 |
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| SMILES | CCc1cc(=O)oc2c(C)c(O)c(CN(C)C)cc12 |
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| Structure | 
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