Reaction Details |
| Report a problem with these data |
Target | Orexin receptor type 2 |
---|
Ligand | BDBM50447804 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1290418 (CHEMBL3119327) |
---|
IC50 | 3.0±n/a nM |
---|
Citation | Sifferlen, T; Boller, A; Chardonneau, A; Cottreel, E; Hoecker, J; Aissaoui, H; Williams, JT; Brotschi, C; Heidmann, B; Siegrist, R; Gatfield, J; Treiber, A; Brisbare-Roch, C; Jenck, F; Boss, C Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1. Bioorg Med Chem Lett24:1201-8 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin receptor type 2 |
---|
Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
|
|
|
BDBM50447804 |
---|
n/a |
---|
Name | BDBM50447804 |
Synonyms: | CHEMBL3113752 | US9242970, 57 |
Type | Small organic molecule |
Emp. Form. | C25H24N2O4 |
Mol. Mass. | 416.4691 |
SMILES | COc1ccnc(OC)c1C1CCCC(=O)N1Cc1ccc2oc3ccccc3c2c1 |
Structure |
|