Reaction Details | |||
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Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ||
Ligand | BDBM50448077 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1292919 (CHEMBL3122824) | ||
IC50 | 3162±n/a nM | ||
Citation | Leivers, AL; Tallant, M; Shotwell, JB; Dickerson, S; Leivers, MR; McDonald, OB; Gobel, J; Creech, KL; Strum, SL; Mathis, A; Rogers, S; Moore, CB; Botyanszki, J Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIa) inhibitors as anti hepatitis C (HCV) agents. J Med Chem57:2091-106 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | |||
Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ||
Synonyms: | PI3-kinase p110 subunit gamma | PI3-kinase subunit p120-gamma | PI3Kgamma | PIK3CG | PK3CG_HUMAN | Phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit gamma (PIK3CG) | Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma (PI3Kgamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3Kgamma) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Phosphoinositide 3-Kinase (PI3K), gamma Chain A | Phosphoinositide 3-kinases gamma (PI3K gamma) | Phosphoinositide-3-kinase (PI3K gamma) | p120-PI3K | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 126470.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P48736 | ||
Residue: | 1102 | ||
Sequence: |
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BDBM50448077 | |||
n/a | |||
Name | BDBM50448077 | ||
Synonyms: | CHEMBL3121308 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H18F5N5O4S | ||
Mol. Mass. | 603.52 | ||
SMILES | COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1 |(6.94,-44.12,;8.27,-43.35,;9.61,-44.12,;9.61,-45.66,;10.94,-46.43,;12.27,-45.66,;12.27,-44.12,;10.94,-43.35,;10.94,-41.8,;12.02,-40.7,;12.43,-42.19,;9.61,-41.03,;9.61,-39.5,;10.94,-38.73,;10.95,-37.19,;9.61,-36.42,;9.62,-34.88,;8.28,-37.18,;8.28,-38.72,;6.94,-39.49,;13.6,-46.43,;13.6,-47.97,;14.93,-48.74,;16.27,-47.96,;17.6,-48.73,;18.94,-47.96,;20.27,-48.72,;18.93,-46.41,;20.25,-45.63,;21.57,-46.4,;22.89,-45.63,;22.89,-44.09,;21.56,-43.33,;20.23,-44.1,;19.45,-42.76,;17.91,-42.77,;20.21,-41.42,;18.67,-41.43,;17.59,-45.65,;17.58,-44.11,;16.27,-46.42,;14.93,-45.66,)| | ||
Structure |