| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-derived growth factor subunit A |
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| Ligand | BDBM99471 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1296291 (CHEMBL3132619) |
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| IC50 | 610±n/a nM |
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| Citation |  Okaniwa, M; Hirose, M; Arita, T; Yabuki, M; Nakamura, A; Takagi, T; Kawamoto, T; Uchiyama, N; Sumita, A; Tsutsumi, S; Tottori, T; Inui, Y; Sang, BC; Yano, J; Aertgeerts, K; Yoshida, S; Ishikawa, T Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. J Med Chem56:6478-94 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-derived growth factor subunit A |
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| Name: | Platelet-derived growth factor subunit A |
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| Synonyms: | PDGF subunit A | PDGF-1 | PDGF1 | PDGFA | PDGFA_HUMAN | Platelet-derived growth factor A chain | Platelet-derived growth factor alpha polypeptide |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24060.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108150 |
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| Residue: | 211 |
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| Sequence: | MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD
TSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIW
PPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACA
TTSLNPDYREEDTGRPRESGKKRKRKRLKPT
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| BDBM99471 |
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| n/a |
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| Name | BDBM99471 |
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| Synonyms: | US8497274, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H18F4N4O3S |
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| Mol. Mass. | 554.515 |
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| SMILES | Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2C#N)cc1NC(=O)Cc1cccc(c1)C(F)(F)F |
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| Structure | 
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