| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase subunit gamma-1 |
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| Ligand | BDBM50448482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1298182 (CHEMBL3130053) |
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| IC50 | 3000±n/a nM |
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| Citation |  Low, WK; Li, J; Zhu, M; Kommaraju, SS; Shah-Mittal, J; Hull, K; Liu, JO; Romo, D Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents. Bioorg Med Chem22:116-25 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase subunit gamma-1 |
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| Name: | DNA polymerase subunit gamma-1 |
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| Synonyms: | DNA Polymerase gamma | DNA nucleotidylexotransferase | DNA polymerase (alpha/delta/epsilon) | DNA polymerase beta | DNA polymerase delta subunit 1 | DNA polymerase eta | DNA polymerase gamma subunit 1 | DNA polymerase iota | DNA polymerase kappa | DNA polymerase lambda | DNA polymerase subunit gamma-1 | DNA-directed DNA/RNA polymerase mu | DPOG1_HUMAN | MDP1 | Mitochondrial DNA polymerase catalytic subunit | POLG | POLG1 | POLGA | PolG-alpha |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 139566.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Enzyme was purchased from Ulrich Hubscher, University of Zurich-Irchel, Switzerland. |
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| Residue: | 1239 |
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| Sequence: | MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQ
VLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPL
PDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGP
EGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLS
PADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMA
ISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVH
RLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPH
PVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYK
EDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQ
QDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTP
KLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHC
LEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALT
ARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQ
AGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAI
LPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAA
VLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQP
FAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWI
SLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCIS
RALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYL
VREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTP
SNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP
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| BDBM50448482 |
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| n/a |
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| Name | BDBM50448482 |
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| Synonyms: | CHEMBL3126408 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H42N2O4S |
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| Mol. Mass. | 526.73 |
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| SMILES | C[C@H]1C\C(C)=C\C=C/C(=O)O[C@@H](Cc2nc(CCCCC(=O)O1)cs2)\C=C(/C)\C=C\C(\C)=C\CN(C)C |r,c:6,t:4| |
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| Structure | 
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