Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50448723 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1297897 (CHEMBL3132110) | ||
IC50 | 8.3±n/a nM | ||
Citation | Goldberg, FW; Dossetter, AG; Scott, JS; Robb, GR; Boyd, S; Groombridge, SD; Kemmitt, PD; Sjögren, T; Gutierrez, PM; deSchoolmeester, J; Swales, JG; Turnbull, AV; Wild, MJ Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. J Med Chem57:970-86 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
| ||
BDBM50448723 | |||
n/a | |||
Name | BDBM50448723 | ||
Synonyms: | CHEMBL3127891 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H21F3N2O3S | ||
Mol. Mass. | 390.42 | ||
SMILES | Cc1nc(OCC(F)(F)F)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.24,wD:15.15,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(36.2,-29.53,;37.66,-30.03,;38.11,-31.5,;39.65,-31.53,;40.53,-32.79,;42.07,-32.65,;42.95,-33.91,;44.49,-33.77,;42.31,-35.31,;44.04,-35,;40.15,-30.07,;38.92,-29.15,;41.48,-29.29,;41.47,-27.75,;42.82,-30.06,;44.15,-29.28,;45.65,-28.9,;45.67,-27.31,;46.73,-26.09,;45.38,-26.54,;45.36,-28.03,;46.68,-28.55,;48.09,-28.22,;49.62,-28.19,;48.12,-26.69,;47.05,-29.48,)| | ||
Structure |